Advances in Current Diabetes Proteomics: From the Perspectives of Label-free Quantification and Biomarker Selection.

Due to its prevalence and negative impacts on both economy and society, the diabetes mellitus (DM) has emerged as a worldwide concern. In light of this, the label-free quantification proteomics (LFQ) and diabetic marker selection methods have been applied to elucidate the underlying mechanisms associated with insulin resistance, explore novel protein biomarkers, and discover innovative therapeutic protein targets.

The purpose of this manuscript is to review and analyze the recent computational advances and development of label-free quantification and diabetic marker selection in diabetes proteomics.Web of Science database, PubMed database and Google Scholar were utilized for searching label-free quantification, computational advances, feature selection and diabetes proteomics.In this study, we systematically review the computational advances of label-free quantification and diabetic marker selection which be applied to get understanding of DM pathological mechanisms.

Firstly, different popular quantification measurements and proteomic quantification tools which have been applied to the diabetes studies are comprehensively discussed. Secondly, a number of popular manipulation methods including transformation, pretreatment (centering, scaling, and normalization), missing value imputation methods and a variety of popular feature selection techniques applied to diabetes proteomic data are overviewed with objective evaluation on their advantages and disadvantage.

GlyH-101

B1087-5.1 10 mM (in 1mL DMSO)
EUR 148.00
Description: GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.

GlyH-101

B1087-50 50 mg
EUR 659.00
Description: GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.

Sulforhodamine 101

80101 500MG
EUR 236.00
Description: Minimum order quantity: 1 unit of 500MG

CUDC-101

A4092-10 10 mg
EUR 137.00
Description: CUDC-101 is a multitargeted inhibitor of histone deacetylase. It is designed to directly inhibit epidermal growth factor receptor (EGFR) and HER2 as well as class I and class II HDACs.

CUDC-101

A4092-200 200 mg
EUR 943.00
Description: CUDC-101 is a multitargeted inhibitor of histone deacetylase. It is designed to directly inhibit epidermal growth factor receptor (EGFR) and HER2 as well as class I and class II HDACs.

CUDC-101

A4092-5.1 10 mM (in 1mL DMSO)
EUR 158.00
Description: CUDC-101 is a multitargeted inhibitor of histone deacetylase. It is designed to directly inhibit epidermal growth factor receptor (EGFR) and HER2 as well as class I and class II HDACs.

CUDC-101

A4092-50 50 mg
EUR 386.00
Description: CUDC-101 is a multitargeted inhibitor of histone deacetylase. It is designed to directly inhibit epidermal growth factor receptor (EGFR) and HER2 as well as class I and class II HDACs.

CUDC-101

A4092-S Evaluation Sample
EUR 81.00
Description: CUDC-101 is a multitargeted inhibitor of histone deacetylase. It is designed to directly inhibit epidermal growth factor receptor (EGFR) and HER2 as well as class I and class II HDACs.

ARP 101

A4433-5 5 mg
EUR 334.00
Description: ARP 101 is a selective MMP-2 inhibitor with IC50 value of 0.81nM.

AT-101

A3196-10 10 mg
EUR 171.00
Description: AT101, a natural product from cottonseed with a BH3-mimetic structure, was identified as a small molecule inhibitor of Bcl-2/Bcl-xL/Mcl-1 that potently induces apoptosis in various cancer cell lines [1].

AT-101

A3196-50 50 mg
EUR 432.00
Description: AT101, a natural product from cottonseed with a BH3-mimetic structure, was identified as a small molecule inhibitor of Bcl-2/Bcl-xL/Mcl-1 that potently induces apoptosis in various cancer cell lines [1].

CUDC-101

1966-25
EUR 555.00

CUDC-101

1966-5
EUR 202.00

AT-101

2380-25
EUR 506.00

AT-101

2380-5
EUR 164.00

LOXO-101

B6176-100 100 mg
EUR 696.00
Description: IC50: low nanomolar range for inhibition of all TRK family membersLOXO-101 is a tropomyosin receptor kinases (TRK) inhibitor.The TRK family of neurotrophin receptors and their neurotrophin ligands regulate neuron growth, differentiation and survival.

LOXO-101

B6176-25 25 mg
EUR 290.00
Description: IC50: low nanomolar range for inhibition of all TRK family membersLOXO-101 is a tropomyosin receptor kinases (TRK) inhibitor.The TRK family of neurotrophin receptors and their neurotrophin ligands regulate neuron growth, differentiation and survival.

LOXO-101

B6176-5 5 mg
EUR 128.00
Description: IC50: low nanomolar range for inhibition of all TRK family membersLOXO-101 is a tropomyosin receptor kinases (TRK) inhibitor.The TRK family of neurotrophin receptors and their neurotrophin ligands regulate neuron growth, differentiation and survival.

Trap 101

B7084-10 10 mg
EUR 373.00

Trap 101

B7084-50 50 mg
EUR 1363.00

Sulforhodamine 101

B7762-100 100 mg
EUR 137.00

Sulforhodamine 101

B7762-250 250 mg
EUR 257.00

Sulforhodamine 101

B7762-500 500 mg
EUR 390.00

UCF 101

C4437-10 10 mg
EUR 186.00
Description: IC50: 9.5 ?MUCF 101 is an inhibitor of Omi/HtrA2. Omi/HtrA2, a mitochondria serine protease with close homology to bacterial HtrA chaperones, is released from the mitochondria in response to apoptotic stimuli.

UCF 101

C4437-25 25 mg
EUR 354.00
Description: IC50: 9.5 ?MUCF 101 is an inhibitor of Omi/HtrA2. Omi/HtrA2, a mitochondria serine protease with close homology to bacterial HtrA chaperones, is released from the mitochondria in response to apoptotic stimuli.

UCF 101

C4437-5 5 mg
EUR 145.00
Description: IC50: 9.5 ?MUCF 101 is an inhibitor of Omi/HtrA2. Omi/HtrA2, a mitochondria serine protease with close homology to bacterial HtrA chaperones, is released from the mitochondria in response to apoptotic stimuli.

LOXO-101

B2291-25
EUR 631.00

LOXO-101

B2291-5
EUR 196.00

KHS-101

B2415-25
EUR 588.00

KHS-101

B2415-5
EUR 185.00

AS 101

B7830-5 5 mg
EUR 171.00
Description: Ammonium tri-chloro(dioxoethylene-O,O?-)tellurate (AS-101), an anti?IL-10 compound, is a nontoxic immunomodulator.AS101 (0.43222.5 ?g/ml) decreased IL-10 production in a dose-dependent manner.

UFP-101

B5128-1 1 mg
EUR 583.00

JI-101

HY-16265 10mM/1mL
EUR 248.00

GlyH-101

HY-18336 10mg
EUR 223.00

MG-101

HY-18964 50mg
EUR 601.00

Sulforhodamine 101

HY-101878 25mg
EUR 119.00

CUDC-101

HY-10223 50mg
EUR 337.00

UCPH-101

HY-10914 100mg
EUR 2184.00

ULK-101

HY-114490 10mg
EUR 911.00

Sulforhodamine 101

GT6456-100MG 100 mg
EUR 158.00

miRZip-101 anti-miR-101 microRNA construct

MZIP101-PA-1 Bacterial Streak
EUR 684.00
  • Category: MicroRNA Tools

KHS 101 hydrochloride

B7717-10 10 mg
EUR 318.00

KHS 101 hydrochloride

B7717-50 50 mg
EUR 1162.00

LOXO-101 sulfate

B2545-25
EUR 414.00

LOXO-101 sulfate

B2545-5
EUR 196.00

ECOS 101 (DH5a

FYE607-10VL 100 µl x 10 vials Ask for price

ECOS 101 (DH5a

FYE607-80VL 100 µl x 10 vials Ask for price

ECOS 101 (DH5a

FYE608-10VL 100 µl x 10 vials Ask for price

ECOS 101 (DH5a

FYE608-80VL 100 µl x 10 vials Ask for price

ECOS 101 (DH5a

FYE609-10VL 100 µl x 10 vials Ask for price

Finally, the guidelines for the efficient use of the computation-based LFQ technology and feature selection methods in diabetes proteomics are proposed.In summary, this review provides guidelines for researchers who will engage in proteomics biomarker discovery and by properly applying these proteomic computational advances, more reliable therapeutic targets will be found in the field of diabetes mellitus.

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