Challenging Bioanalyses with Capillary Electrophoresis.

This report covers advances in capillary electrophoresis (CE) from January 2018 through September 2019. A summary of the literature during this time period is insightful. A search performed using the SciFinder Scholar database for journal reports (limited to English) using the term capillary electrophoresis returned approximately 1,800 publications.

Further analysis of this list provided a snapshot of activity in biomolecular research. Classes of biomolecules most frequently associated with CE publications were proteins, drugs, DNA and metabolites. Another measure of the impact of CE is the translation of this technology into society.

A search of patent activity illustrating this process of CE technology transfer returned 346 patents published in all languages, with a substantial contribution reported only in Chinese (198 patents) or English (98 patents).

Established applications of CE continued to serve as the gold standard for molecular separations providing analytical assays, enantiomeric resolution and DNA analyses for human identification. The versatility of CE for biological systems is exemplified by the rise of the technique in several areas. Metabolomics research involving measurements of large sets of molecules with subtle structural differences benefits from rapid separations achieved with high peak capacity and automated instruments.

Single cell and sub-cellular analyses continue to progress in CE because of the size compatibility of the technique with the sample. Other examples of areas utilizing CE that are accelerating include portable and printable instrumentation, affinity interaction, as well as proteomics. As an established analytical tool, CE instrumentation and methods have been designed to be accessible and easily adopted by researchers with expertise in areas beyond the field of separations.

UCF 101

C4437-25 25 mg
EUR 354
Description: IC50: 9.5 ?MUCF 101 is an inhibitor of Omi/HtrA2. Omi/HtrA2, a mitochondria serine protease with close homology to bacterial HtrA chaperones, is released from the mitochondria in response to apoptotic stimuli.

UCF 101

C4437-5 5 mg
EUR 145
Description: IC50: 9.5 ?MUCF 101 is an inhibitor of Omi/HtrA2. Omi/HtrA2, a mitochondria serine protease with close homology to bacterial HtrA chaperones, is released from the mitochondria in response to apoptotic stimuli.

LOXO-101

B2291-25
EUR 631

LOXO-101

B2291-5
EUR 196

KHS-101

B2415-25
EUR 588

KHS-101

B2415-5
EUR 185

LOXO-101

B6176-100 100 mg
EUR 696
Description: IC50: low nanomolar range for inhibition of all TRK family membersLOXO-101 is a tropomyosin receptor kinases (TRK) inhibitor.The TRK family of neurotrophin receptors and their neurotrophin ligands regulate neuron growth, differentiation and survival.

LOXO-101

B6176-25 25 mg
EUR 290
Description: IC50: low nanomolar range for inhibition of all TRK family membersLOXO-101 is a tropomyosin receptor kinases (TRK) inhibitor.The TRK family of neurotrophin receptors and their neurotrophin ligands regulate neuron growth, differentiation and survival.

LOXO-101

B6176-5 5 mg
EUR 128
Description: IC50: low nanomolar range for inhibition of all TRK family membersLOXO-101 is a tropomyosin receptor kinases (TRK) inhibitor.The TRK family of neurotrophin receptors and their neurotrophin ligands regulate neuron growth, differentiation and survival.

GlyH-101

B1087-10 10 mg
EUR 195
Description: GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.

GlyH-101

B1087-5.1 10 mM (in 1mL DMSO)
EUR 148
Description: GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.

GlyH-101

B1087-50 50 mg
EUR 659
Description: GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.

UFP-101

B5128-1 1 mg
EUR 583

Trap 101

B7084-10 10 mg
EUR 373

Trap 101

B7084-50 50 mg
EUR 1363

Sulforhodamine 101

B7762-100 100 mg
EUR 137

Sulforhodamine 101

B7762-250 250 mg
EUR 257

Sulforhodamine 101

B7762-500 500 mg
EUR 390

AS 101

B7830-5 5 mg
EUR 171
Description: Ammonium tri-chloro(dioxoethylene-O,O?-)tellurate (AS-101), an anti?IL-10 compound, is a nontoxic immunomodulator.AS101 (0.43222.5 ?g/ml) decreased IL-10 production in a dose-dependent manner.

Sulforhodamine 101

HY-101878 25mg
EUR 119

CUDC-101

HY-10223 50mg
EUR 337

UCPH-101

HY-10914 100mg
EUR 2184

JI-101

HY-16265 10mM/1mL
EUR 248

GlyH-101

HY-18336 10mg
EUR 223

MG-101

HY-18964 50mg
EUR 601

ULK-101

HY-114490 10mg
EUR 911

Sulforhodamine 101

GT6456-100MG 100 mg
EUR 158

Sulforhodamine 101

80101 500MG
EUR 236
Description: Minimum order quantity: 1 unit of 500MG

CUDC-101

A4092-10 10 mg
EUR 137
Description: CUDC-101 is a multitargeted inhibitor of histone deacetylase. It is designed to directly inhibit epidermal growth factor receptor (EGFR) and HER2 as well as class I and class II HDACs.

CUDC-101

A4092-200 200 mg
EUR 943
Description: CUDC-101 is a multitargeted inhibitor of histone deacetylase. It is designed to directly inhibit epidermal growth factor receptor (EGFR) and HER2 as well as class I and class II HDACs.

CUDC-101

A4092-5.1 10 mM (in 1mL DMSO)
EUR 158
Description: CUDC-101 is a multitargeted inhibitor of histone deacetylase. It is designed to directly inhibit epidermal growth factor receptor (EGFR) and HER2 as well as class I and class II HDACs.

CUDC-101

A4092-50 50 mg
EUR 386
Description: CUDC-101 is a multitargeted inhibitor of histone deacetylase. It is designed to directly inhibit epidermal growth factor receptor (EGFR) and HER2 as well as class I and class II HDACs.

CUDC-101

A4092-S Evaluation Sample
EUR 81
Description: CUDC-101 is a multitargeted inhibitor of histone deacetylase. It is designed to directly inhibit epidermal growth factor receptor (EGFR) and HER2 as well as class I and class II HDACs.

ARP 101

A4433-5 5 mg
EUR 334
Description: ARP 101 is a selective MMP-2 inhibitor with IC50 value of 0.81nM.

AT-101

A3196-10 10 mg
EUR 171
Description: AT101, a natural product from cottonseed with a BH3-mimetic structure, was identified as a small molecule inhibitor of Bcl-2/Bcl-xL/Mcl-1 that potently induces apoptosis in various cancer cell lines [1].

AT-101

A3196-50 50 mg
EUR 432
Description: AT101, a natural product from cottonseed with a BH3-mimetic structure, was identified as a small molecule inhibitor of Bcl-2/Bcl-xL/Mcl-1 that potently induces apoptosis in various cancer cell lines [1].

CUDC-101

1966-25
EUR 555

CUDC-101

1966-5
EUR 202

AT-101

2380-25
EUR 506

AT-101

2380-5
EUR 164

miRZip-101 anti-miR-101 microRNA construct

MZIP101-PA-1 Bacterial Streak
EUR 684
  • Category: MicroRNA Tools

LOXO-101 sulfate

B2545-25
EUR 414

LOXO-101 sulfate

B2545-5
EUR 196

KHS 101 hydrochloride

B7717-10 10 mg
EUR 318

KHS 101 hydrochloride

B7717-50 50 mg
EUR 1162

ECOS 101 (DH5a

FYE607-10VL 100 µl x 10 vials Ask for price

ECOS 101 (DH5a

FYE607-80VL 100 µl x 10 vials Ask for price

ECOS 101 (DH5a

FYE608-10VL 100 µl x 10 vials Ask for price

ECOS 101 (DH5a

FYE608-80VL 100 µl x 10 vials Ask for price

ECOS 101 (DH5a

FYE609-10VL 100 µl x 10 vials Ask for price

Generally, publications including CE measurements either outline innovations in the technique or they are compelling applications of a mature analytical approach. The goal of this review, which is limited to 180 citations, is to communicate an overview of recent developments, focusing on reports describing advances to the technology. Although publications that utilize CE are found in a diverse set of periodicals, the reports included in this review are from journals that are popular in the field of analytically-based separation chemistry.